A 68-year-old male patient is brought to the Emergency Department with oliguria, hyperkalaemia, and severe metabolic acidosis. His serum creatinine has risen from a baseline of 103 μmol/L to 315 μmol/L over the past 48 hours.
Which of the following is the most appropriate indication for initiating Renal Replacement Therapy (RRT) in this patient with Acute Kidney Injury (AKI)?
A
Serum creatinine > 300 μmol/L
B
Oliguria for more than 12 hours
C
Severe metabolic acidosis (pH < 7.1) after IVF
D
Hyperkalaemia 7.0 mmol/L before treatment
E
Rise in creatinine by > 106 μmol/L from baseline